Hypo Awareness Week was first staged locally in hospitals in Portsmouth in April 2012 before being rolled out nationally by NHS Diabetes the following August. Oliver Jelley worked for NHS Diabetes and organised the first national Hypo Awareness Week, introducing the concept of an online resource pack. NHS Diabetes closed in April 2013 but Oliver continued the running of the national campaign through Orange Juice Communications.

Hospitals and primary care organisations register and are sent a link to an online pack of materials and then encouraged to hold activities and training throughout the week. A suite of materials is created and placed on a dedicated webpage. The online resource pack includes posters, leaflets, guidelines, logos, screensavers and a press release template as well as instructions to give participants ideas and tips on how to organise the week. A printed resource pack is also sent out to registered sites, including posters, leaflets, balloons and t-shirts.